With a number of highly ranked teams playing each other and rivalry games throughout the schedule, Week 13 is undoubtedly shaping up to be the most important slate of contests in the 2015 college football season thus far.

The College Football Playoff picture remains unsettled, which means the door is open for several teams to make their case. At the same time, a single loss can crush a school’s dreams and eliminate it from contention for the national championship.

Ahead of what is shaping up to be the most exciting week in college football in quite some time, here is a full rundown of every Top 25 game, along with predictions for who will come out on top in each.

Breaking Down Top Games

(5) Oklahoma at (9) Oklahoma State

The annual Bedlam between Oklahoma and Oklahoma State is always significant, but this year’s is even bigger as both the Sooners and Cowboys have one loss, which means the loser will almost certainly be out of the CFP conversation.

Oklahoma’s only loss came in a rivalry game against Texas, while the Pokes fell this past week to Baylor. The Sooners may very well control their own destiny with regard to the College Football Playoff since they beat the Bears already, but they will have their hands full Saturday night.

OU defeated TCU 30-29 in Week 12, but it nearly relinquished a big lead after star quarterback Baker Mayfield exited the game with a head injury.

His status for Bedlam is very much in question as head coach Bob Stoops is unsure of where he stands currently, according to ESPN.com’s Jake Trotter.

Per Trotter, defensive coordinator Mike Stoops knows how huge being without a player of Mayfield’s caliber would be: “Losing Baker hurt us,” Stoops said. “He’s our leader. He inspires us all, in a lot of ways.”

Mayfield is having a big year with 33 touchdown passes and just five interceptions, and while backup Trevor Knight is experienced, he has been extremely inconsistent over the course of his career.

As pointed out by ESPN.com’s Travis Haney, the powers-that-be within the Big 12 are likely rooting for the Sooners since wins over Baylor, TCU and Oklahoma State would make a compelling case to the CFP committee.

Suddenly Baker Mayfield’s health going to be very important to monitor going into Bedlam. Big 12 really needs OU to win out. Best CFP case.

— Travis Haney (@TravHaneyESPN) November 22, 2015

Doing so in Stillwater, Oklahoma, either without Mayfield or with Mayfield at less than 100 percent, is an extremely tall order, though.

Cowboys quarterback Mason Rudolph is having a strong year in his own right with 3,591 yards and 21 touchdowns. He is coming off a 430-yard performance against Baylor, and his recent excellent play will lead Oklahoma State to victory.

(8) Ohio State at (12) Michigan

The rivalry between Ohio State and Michigan is arguably the biggest in college football, and it has certainly regained some of its luster this year due to the Wolverines’ rapid improvement under head coach Jim Harbaugh.

Michigan is an impressive 9-2, and if not for a miraculous touchdown by Michigan State on the final play of the game several weeks ago, it would be 10-1 and very much in the CFP picture.

Ohio State is the reigning national champion, but after falling to the Spartans 17-14, the Buckeyes may not be back in the final four this time around.

Despite having just one loss, current indications are that OSU will enter the Big House as an underdog, which has been a rare occurrence in recent years, per Drew Hallett of Maize N Blue:

If Michigan-Ohio State line holds, it’d be the first time OSU is an underdog this year. Also, just the second time vs. U-M since 2004.

— Drew Hallett (@DrewCHallett) November 22, 2015

The Buckeyes may very well have more talent than the Wolverines, but they have played with fire all season long and finally got burned in the form of a loss to MSU. Their quarterback situation has been a mess with J.T. Barrett and Cardale Jones, and now, perhaps, Ohio State’s best player is disgruntled.

According to ESPN.com’s Austin Ward, running back Ezekiel Elliott was extremely displeased that he was only given 12 carries against the Spartans:

Honestly, this is my last game in the Shoe. I mean, there’s no chance of me coming back next year. … What happened today, it was kind of like a bad, bad dream. Offense had a rough day, and I’m disappointed. I’m disappointed in the play calling, I’m disappointed in the situations we were put in, and I wish it all played out differently.

With Elliott sounding as though he has mentally checked out of the season, it is fair to wonder if the Buckeyes are equipped to beat their greatest rival on the road.

Focus certainly hasn’t been an issue for Harbaugh’s squad in 2015, and it’ll undoubtedly be motivated to beat Ohio State after so many years of being an also-ran in the Big Ten.

Because of the energy that Harbaugh has brought to Michigan, the Wolverines are in an ideal position to finally get a big win over OSU.

(4) Notre Dame at (13) Stanford

Notre Dame was in the Top Four of the most recent CFP poll, but in order to keep its spot, ND will have to defeat Stanford on the road in Week 13.

The Cardinal have two losses, but they still have an outside shot at the College Football Playoff if they win out and get some help, so they will have every reason to turn in a great performance Saturday.

In addition to that, Stanford may very well have the new Heisman Trophy front-runner on its team in the form of running back Christian McCaffrey. The son of former Denver Broncos wide receiver Ed McCaffrey has nearly 2,000 yards from scrimmage this season, and he racked up a school-record 389 all-purpose yards in Week 12, according to Stewart Mandel of Fox Sports 1.

Stanford head coach David Shaw firmly believes that McCaffrey has proven himself to be the best all-round player in college football this season, per Paul Ladewski of the San Francisco Examiner: “Has anyone seen a better football player in the country than Christian McCaffrey?” Shaw said. “Tell me. Show him to me.”

McCaffrey has been great, but Notre Dame is on a six-game winning streak since losing by just two points to No. 1 Clemson.

Quarterback DeShone Kizer has been a revelation for the Irish, and he must be at his best in order to combat what McCaffrey brings to the table.

This may very well turn out to be the best and closest among the huge Week 13 college football games, but home-field advantage will ultimately be the difference, with Stanford keeping its CFP hopes alive.

Follow @MikeChiari on Twitter.