This could be the most exciting game of the weekend.

By the end of the night, one team’s playoff hopes will likely be extinguished as neither can afford a loss.

Clemson’s MacKensie Alexander vs. Notre Dame’s Will Fuller is a terrific matchup to watch.

Alexander has the makings of a shutdown corner, while Fuller is a dynamic receiver. The former doesn’t lack confidence as he told Brad Senkiw of blog site Orange and White that he’s the best corner in college football.

“I think every guy that talks about Mackensie knows I’m the best corner in college football,” Alexander said. “Look at my body of work, the things I’ve done. It’s not even close.”

Quarterbacks have shied away from throwing at Alexander, and he’s given up just two touchdowns in his career.

Meanwhile, Fuller has been a touchdown machine, recording six on the year. He has 454 yards in four games, including at least 100 yards in each of the first three.

Keep an eye on that heavyweight battle.

Texas A&M has a deep receiving corps. 

Despite a relatively quiet start from Speedy Noil and Edward Pope, Josh Reynolds has been been excellent by tallying 242 yards on 11 receptions and hauling in three touchdown passes.

Freshman Christian Kirk has been absolutely dominant. He has 442 yards and averages 110.5 yards per game. He has nine receptions that have gone for at least 20 yards and four touchdown grabs.

It will be up to defensive end A.J. Jefferson and linebacker Richie Brown to help MSU’s cornerbacks out by limiting the amount of time A&M has to throw the football. 

The Aggies offensive line hasn’t played well this season which means Jefferson and Brown should frequently break through. 

Like A&M, Mississippi has a talented group of receivers.

Watching them go up against Florida’s defensive backs should be a fun battle to watch.

Laquon Treadwell is a 6-foot-2 receiver who has 332 yards on 22 catches, while Quincy Adeboyejo has 224 yards on 10 receptions and leads the team with five touchdown catches.

Vernon Hargreaves III is Florida’s top corner and has two interceptions. 

Greg Ostendorf of ESPN reported Treadwell is looking forward to the matchup with Hargreaves III. Treadwell admitted:

It’s a bragging-rights game. He got the best of me in the All-America game. But I don’t really want to make this about matchups. We’re 4-0. They’re 4-0. He’s going to do whatever he can to make his team win. I’m going to do whatever I can to make my team win. At the end of the game, we’ll see who has the best performance.

Can Georgia prove it’s deserving of playoff consideration with a win over Alabama?

The spotlight will be on Georgia’s running game vs. Alabama’s defense.

Alabama has the No. 4 rushing defense in the nation. The Crimson Tide give up just 1.97 yards per rush attempt and 56.8 rushing yards per game. They will have their hands full with running back Nick Chubb.

Chubb has 599 yards this season and has recorded at least 100 yards in each of his first four games.

Can West Virginia’s defensive backs slow down Oklahoma’s receivers?

The Sooners have a prolific passing offense that ranks No. 8 in the nation. Oklahoma accumulates 371 yards per game through the air and has 10 touchdown passes on the season.

Sterling Shepard has been excellent for Oklahoma so far with 286 yards on 18 catches.

Meanwhile, West Virginia’s passing defense is No. 17 and has given up just two touchdown passes. 

Is Michigan State the No. 2 team in the nation?

That’s been a topic of debate after two lackluster wins over teams the Spartans should have dominated.

Can the secondary put together a great performance against Purdue’s offense and gain some confidence?

That remains to be seen. 

Can Indiana outscore Ohio State?

The Hoosiers offense ranks No. 18 nationally and No. 1 in the Big Ten. 

Quarterback Nate Sudfeld has thrown for 1,143 yards, with seven touchdowns and only one interception.

Yet their defense is giving up 499 yards per game, according to cfbstats.com. That won’t get the job done against the No. 1 team in the nation.

Maryland’s offense vs. Michigan’s defense will play a factor in the outcome.

The Terrapins need a better performance from quarterback Caleb Rowe, who has thrown nine interceptions on the year and averages just 95.3 yards through the air.

For the Wolverines, they have the No. 2 defense in the nation and limit teams to 203.8 total yards per game.

Oregon is looking to get back on track.

The Ducks need a bounce-back performance from their defense that struggled to put pressure on Utah’s quarterback in last week’s loss.

Sefo Liufau is a dual-threat quarterback and could give Oregon’s defense trouble. He’s thrown for 771 yards this season and has just one interception.

Can Wisconsin stop Iowa’s run game?

Jordan Canzeri has eight touchdowns, 316 rushing yards and compiled 23 first downs so far.

This game gives Canzeri an opportunity to shine against a ranked opponent and give the Hawkeyes a lift in the Big Ten standings.